VDR is a Virtual Data Room that provides secure, reliable access to confidential documents used in business transactions. VDRs are a great tool for performing due diligence during mergers and acquisitions. They also assist businesses organize important documents and share them with investors and other stakeholders. VDRs can also be used to store and manage invoices, contracts and other legal documents like litigation and estate planning.
Members should review the procedures and equipment that are installed on their vessels equipped with a VDR/SVDR. It is also recommended to to look at upgrading and replacing those that are inefficient or are not in compliance with the minimum safety requirements.
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes regulate the expression of proteins that play a role in a variety of physiological processes.
The VDR can be found in neurons, glial cells and subsets of them that form part of the brain. In hippocampal cultures of the primary rat, immunoreactivity for the VDR was detected in oligodendrocytes. The VDR is also found in human neuroblastoma as well as astrocytes. The treatment of leukemia cells from HL-60 by 1,25(OH2)2D3 resulted in monocyte-like differentiation, as well as higher VDR levels. This effect was prevented by inhibitors of PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.